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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Local therapy with CpG motifs in a murine model of allergic airway inflammation in IFN-β knock-out mice. | Respiratory Research BioMed Central Research Open Access Local therapy with CpG motifs in a murine model of allergic airway inflammation in IFN-P knock-out mice Victor Matheu 1 2 Alexandra Treschow1 Ingrid Teige1 Vaidrius Navikas1 and Shohreh Issazadeh-Navikas1 Address 1Section of Medical Inflammation Research Department of Cell Molecular Biology Lund University Sweden and 2Fundación Rafael Clavijo de Investigación Biomédica Tenerife Spain Email Victor Matheu - Victor.Matheu@inflam.lu.se Alexandra Treschow - Alexandra.Treschow@inflam.lu.se Ingrid Teige - Ingrid.Teige@inflam.lu.se Vaidrius Navikas - Victor.Matheu@inflam.lu.se Shohreh Issazadeh- Navikas - Shohreh.Issazadeh@inflam.lu.se Corresponding author Published 05 March 2005 Respiratory Research 2005 6 25 doi 10.1186 1465-9921 -6-25 Received 28 June 2004 Accepted 05 March 2005 This article is available from http respiratory-research.cOm content 6 1 25 2005 Matheu et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background CpG oligodeoxynucleotides CpG-ODN are capable of inducing high amounts of type I IFNs with many immunomodulatory properties. Furthermore type-I IFNs have been proposed to play a key role in mediating effects of CpG-ODN. The precise role of IFN-P in the immunomodulatory effects of CpG-ODN is not known. Objective Here we aimed to elucidate the role of IFN-P in the anti-allergic effect of CpG motifs. Methods We assessed the immune response in OVA-primed OVA-challenged IFN-P knockout - - mice compared to wild type WT control after intranasal and systemic treatment with synthetic CpG motifs. Results Vaccination with CpG-ODN reduced the number of cells in airways of OVA-sensitized WT but not IFN-P- - mice. Although airway eosinophilia was .
