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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " The gene encoding interleukin-13: a susceptibility locus for asthma and related traits | http respiratory-research.eom content 1 1 019 Commentary The gene encoding interleukin-13 a susceptibility locus for asthma and related traits Marsha Wills-Karp Johns Hopkins University Baltimore Maryland USA Received 14 April 2000 Revisions requested 3 May 2000 Revisions received 20 June 2000 Accepted 3 July 2000 Published 17 July 2000 Respir Res 2000 1 19-23 Current Science Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract Asthma is a complex inflammatory disorder controlled by both genetic and environmental influences. Multiple genetic analyses have identified the T helper type 2 Th2 cytokine gene cluster on chromosome 5q as a susceptibility locus for asthma. Recently the Th2 cytokine interleukin-13 has been shown to be a critical mediator of the asthma phenotype in murine models. In this commentary we discuss several recent studies that have identified polymorphisms in the gene encoding interleukin-13. The consistent genetic associations of interleukin-13 with asthma and related traits across diverse ethnic populations in these studies provides strong support for the candidacy of this cytokine as a susceptibility locus for asthma and atopy on chromosome 5q31. Keywords asthma atopy genetics interleukin-4 receptor interleukin-13 Asthma is a complex inflammatory lung disease controlled by both environmental and genetic factors. Although the exact genes controlling susceptibility to asthma have not been identified several genome-wide searches have provided evidence for the linkage of asthma or asthma-related traits serum IgE levels skin test reactivity bronchial hyper-responsiveness blood eosinophils to loci on multiple autosomal chromosomes 1-6 . Of particular interest is the 5q31-33 region which contains the T helper type 2 Th2 cytokine gene cluster interleukin IL -4 IL-13 IL-5 and IL-9 and has been linked to asthma or related phenotypes in many studies 2-8 . In addition to the linkage data many human and animal studies have implicated these cytokines .
