Đang chuẩn bị nút TẢI XUỐNG, xin hãy chờ
Tải xuống
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Antibodies of IgG, IgA and IgM isotypes against cyclic citrullinated peptide precede the development of rheumatoid arthritis. | Kokkonen et al. Arthritis Research Therapy 2011 13 R13 http arthritis-research.eom content 13 1 R13 RESEARCH ARTICLE Open Access Antibodies of IgG IgA and IgM isotypes against cyclic citrullinated peptide precede the development of rheumatoid arthritis 1 2 1 3 4 2 Heidi Kokkonen Mohammed Mullazehi Ewa Berglin Goran Hallmans Goran Wadell Johan Ronnelid Solbritt Rantapaa-Dahlqvist1 Abstract Introduction We and others have previously shown that antibodies against cyclic citrullinated proteins anti-CCP precede the development of rheumatoid arthritis RA and in a more recent study we reported that individuals who subsequently developed RA had increased concentrations of several cytokines and chemokines years before the onset of symptoms of joint disease. Here we aimed to evaluate the prevalence and predictive values of anti-CCP antibodies of IgG IgM and IgA isotype in individuals who subsequently developed RA and also to relate these to cytokines and chemokines smoking genetic factors and radiographic score. Methods A case-control study 1 4 ratio was nested within the Medical Biobank and the Maternity cohorts of Northern Sweden. Patients with RA were identified from blood donors predating the onset of disease by years. Matched controls were selected randomly from the same registers. IgG IgA and IgM anti-CCP2 antibodies were determined using EliA anti-CCP assay on ImmunoCAP 250 Phadia AB Uppsala Sweden . Results Of 86 patients with RA identified as blood donors prior to the onset of symptoms samples were available from 71 for analyses. The median Q1 to Q3 predating time was 2.5 years 1.1 to 5.9 years . The sensitivity of anti-CCP antibodies in the pre-patient samples was 35.2 for IgG 23.9 for IgA and 11.8 for IgM. The presence of IgG and IgA anti-CCP antibodies was highly significant compared with controls. IgG and IgA anti-CCP2 predicted RA significantly in conditional logistic regression models odds ratio OR 94.1 95 confidence interval CI 12.7 to 695.4 and OR 11.1 95 CI
