TAILIEUCHUNG - Báo cáo y học: "Diagnostic value and clinical laboratory associations of antibodies against recombinant ribosomal P0, P1 and P2 proteins and their native heterocomplex in a Caucasian cohort with systemic lupus erythematosus"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Diagnostic value and clinical laboratory associations of antibodies against recombinant ribosomal P0, P1 and P2 proteins and their native heterocomplex in a Caucasian cohort with systemic lupus erythematosus. | Barkhudarova et al. Arthritis Research Therapy 2011 13 R20 http content 13 1 R20 RESEARCH ARTICLE Open Access Diagnostic value and clinical laboratory associations of antibodies against recombinant ribosomal P0 P1 and P2 proteins and their native heterocomplex in a Caucasian cohort with systemic lupus erythematosus Fidan Barkhudarova1 Cornelia Dahnrich2 Anke Rosemann2 Udo Schneider1 Winfried Stocker2 11 21 1 Gerd-Rudiger Burmester Karl Egerer Wolfgang Schlumberger Falk Hiepe Robert Biesen Abstract Introduction In this study we sought to determine the diagnostic value and clinical laboratory associations of autoantibodies against recombinant ribosomal P0 P1 and P2 proteins and their native heterocomplex in systemic lupus erythematosus SLE . Methods Autoantibodies against recombinant ribosomal P proteins aRibPR0 aRibPR1 and aRibPR2 and antibodies against native ribosomal P heterocomplex aRibPNH were determined in sera from patients with SLE n 163 systemic sclerosis n 66 Sjogren s syndrome n 54 rheumatoid arthritis n 90 and healthy donors n 100 using enzyme-linked immunosorbent assay. Test results were correlated to medical records including the American College of Rheumatology criteria the Systemic Lupus Erythematosus Disease Activity Index 2000 laboratory data and medications of all SLE patients. Results Sensitivities of for aRibPR0 for aRibPR2 for aRibPNH and for aRibPR1 were obtained at a specificity of 99 . The assay for aRibPR0 detection demonstrated the best performance in receiveroperating characteristics analysis with aRibPR0 detectable in 10 of anti-Smith antibody and anti-double-stranded DNA-negative sera at a specificity of 100 . ARibPR0 positivity was associated with lymphocytopenia. ARibPR1 patients had significantly higher g-glutamyl transpeptidase GGT levels than their aRibPR1- counterparts. No specific damage occurred in aRibP lupus patients compared with a group of age- sex- and nephritis-matched aRibP-lupus

TÀI LIỆU LIÊN QUAN
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.