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From the emergence of clinical sleep medicine marked by the establishment of the harbinger Stanford Sleep Disorders Clinic in the mid 1970s, offspring sleep disorders clinics and centers have grown exponentially with the recognition of the unmet diagnostic and treatment needs of the reservoir of patients suffering from symptoms of what are now recognized and classified as the nosology of human sleep disorders. Important in the growing armamentarium of treatment options for the sleep practitioner are both traditional and newer pharmacological agents, including over-the-counter, non-traditional, and prescription types, that are all used to treat, sometimes adjunctively, most clinically recognized sleep disorders | Clinical Pharmacology of Sleep Edited by S.R. Pandi-Perumal and J.M. Monti Birkhauser Verlag Basel Boston Berlin S.R. Pandi-Perumal Comprehensive Center for Sleep Medicine Department of Pulmonary Critical Care and Sleep Medicine Mount Sinai School of Medicine 1176 5th Avenue New York NY 10029 USA Jaime M. Monti Pharmacology and Therapeutics 2833 602 Zudanez Street Montevideo 11300 Uruguay A CIP catalogue record for this book is available from the Library of Congress Washington D.C. USA Bibliographic information published by Die Deutsche Bibliothek Die Deutsche Bibliothek lists this publication in the Deutsche Nationalbibliografie detailed bibliographic data is available in the Internet at http dnb.ddb.de . ISBN 10 3-7643-7262-1 Birkhauser Verlag Basel - Boston - Berlin ISBN 13 978-3-7643-7262-0 The publisher and editor can give no guarantee for the information on drug dosage and administration contained in this publication. The respective user must check its accuracy by consulting other sources of reference in each individual case. The use of registered names trademarks etc. in this publication even if not identified as such does not imply that they are exempt from the relevant protective laws and regulations or free for general use. This work is subject to copyright. All rights are reserved whether the whole or part of the material is concerned specifically the rights of translation reprinting re-use of illustrations recitation broadcasting reproduction on microfilms or in other ways and storage in data banks. For any kind of use permission of the copyright owner must be obtained. 2006 Birkhauser Verlag P.O. Box 133 CH-4010 Basel Switzerland Part of Springer Science Business Media Printed on acid-free paper produced from chlorine-free pulp. TCF TO Printed in Germany Cover design Micha Lotrovsky 4106 Therwil Switzerland Cover illustration midline sagittal T2-weighted magnetic resonance image of the head with a color gradient applied to the brain. Regions of dark .
