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The subspecialty of population pharmacokinetics was introduced into clinical pharmacology / pharmacy in the late 1970s as a method for analyzing observational data collected during patient drug therapy in order to estimate patient-based pharmacokinetic parameters. It later became the basis for dosage individualization and rational pharmacotherapy. The population pharmacokinetics method (i.e., the population approach) was later extended to the characterization of the relationship between pharmacokinetics and pharmacodynamics, and into the discipline of pharmacometrics. Pharmacometrics is the science of interpreting and describing pharmacology in a quantitative fashion. Vast amounts of data are generated during clinical trials and patient care, and it is the responsibility of the pharmacometrician to extract the knowledge. | WILEY PHARMACOMETRICS The Science of Quantitative Pharmacology Edited by Ene I. Ette Paul J. Williams PHARMACOMETRICS BICENTENNIAL ĩ 1 807 s @WILEY I J 2007 ã . Jr BICENTENNIAL The Wiley Bicentennial-Knowledge for Generations ach generation has its unique needs and aspirations when Charles Wiley first opened his small printing shop in lower Manhattan in 1807 it was a generation of boundless potential searching for an identity. And we were there helping to define a new American literary tradition. Over half a century later in the midst of the Second Industrial Revolution it was a generation focused on building the future. Once again we were there supplying the critical scientific technical and engineering knowledge that helped frame the world. Throughout the 20th Century and into the new millennium nations began to reach out beyond their own borders and a new international community was bom. Wiley was there expanding its operations around the world to enable a global exchange of ideas opinions and know-how. For 200 years Wiley has been an integral part of each generation s journey enabling the flow of information and understanding necessary to meet their needs and fulfill their aspirations. Today bold new technologies are changing the way we live and learn. Wiley will be there providing you the must-have knowledge you need to imagine new worlds new possibilities and new opportunities. Generations come and go but you can always count on Wiley to provide you the knowledge you need when and where you need it William J. PESCE PETER BOOTH Wiley President and Chief Executive Officer Chairman of the .
