TAILIEUCHUNG - PHARMACOMETRICS THE SCIENCE OF QUANTITATIVE PHARMACOLOGY

The subspecialty of population pharmacokinetics was introduced into clinical pharmacology / pharmacy in the late 1970s as a method for analyzing observational data collected during patient drug therapy in order to estimate patient-based pharmacokinetic parameters. It later became the basis for dosage individualization and rational pharmacotherapy. The population pharmacokinetics method (., the population approach) was later extended to the characterization of the relationship between pharmacokinetics and pharmacodynamics, and into the discipline of pharmacometrics. Pharmacometrics is the science of interpreting and describing pharmacology in a quantitative fashion. Vast amounts of data are generated during clinical trials and patient care, and it is the responsibility of the pharmacometrician to extract the knowledge. | WILEY PHARMACOMETRICS The Science of Quantitative Pharmacology Edited by Ene I. Ette Paul J. Williams PHARMACOMETRICS BICENTENNIAL ĩ 1 807 s @WILEY I J 2007 ã . Jr BICENTENNIAL The Wiley Bicentennial-Knowledge for Generations ach generation has its unique needs and aspirations when Charles Wiley first opened his small printing shop in lower Manhattan in 1807 it was a generation of boundless potential searching for an identity. And we were there helping to define a new American literary tradition. Over half a century later in the midst of the Second Industrial Revolution it was a generation focused on building the future. Once again we were there supplying the critical scientific technical and engineering knowledge that helped frame the world. Throughout the 20th Century and into the new millennium nations began to reach out beyond their own borders and a new international community was bom. Wiley was there expanding its operations around the world to enable a global exchange of ideas opinions and know-how. For 200 years Wiley has been an integral part of each generation s journey enabling the flow of information and understanding necessary to meet their needs and fulfill their aspirations. Today bold new technologies are changing the way we live and learn. Wiley will be there providing you the must-have knowledge you need to imagine new worlds new possibilities and new opportunities. Generations come and go but you can always count on Wiley to provide you the knowledge you need when and where you need it William J. PESCE PETER BOOTH Wiley President and Chief Executive Officer Chairman of the .

• Y học thường thức
• Drug Development
• Pharmacometric Modeling
• Disease Progression
• Mechanistic Pharmacokinetic
• Estimation Methods
• of Drug Metabolism
• Drug Metabolite
• Quantitative Drug Metabolism
• Development Processes
• Drug Discovery
• Drug Metabolism
• Medicinal Chemistry
• BMC Bioinformatics
• Drug target relations
• Compound protein relations
• Drug repositioning
• Biological effect
• Molecular histopathology
• Tissue biomarkers in drug
• Diagnostic development
• Final recommendations
• Three companion diagnostic development paths
• Companion diagnostics
• Development of solidified self microemulsifying drug delivery systems containing L tetrahydropalmatine
• Design of experiment approach and bioavailability comparison
• Solidified self microemulsifying drug delivery systems containing L tetrahydropalmatine
• Pellet SMEDDS in the rabbit model
• Cardiovascular pharmacotherapeutics
• Complementarymedicine for preventing
• Treatingcardiovascular disease
• Cardiovascular drug–drug interactions
• Drug treatment of peripheral vascular disorders
• Cardiovascular drugs in development
• Pediatric cardiovascular pharmacology
• Carbohydrate polymers
• Pulmonary drug delivery
• Biodegradable polymer
• Biocompatible polymer
• Drug carrier
• Natural products
• Microbial biocatalysts
• Pharmaceutical products
• Microbial biotransformation
• Drug development based
• Natural products from mevalonic acid pathway
• BMC Musculoskeletal Disorders
• Synovial biopsy
• Rheumatoid arthritis
• Signalling pathways
• Joint deformity
• Principles of pharmacology
• The pathophysiologic basis of drug therapy
• Principles of chemotherapy
• Environmental toxicology
• Frontiers in pharmacology
• Fundamentals of drug development
• Embryonic development
• Zinc chloride
• Zebrafish embryos
• Drug development technologies
• Early life stage
• Polysaccharides for Colon
• Targeted Drug Delivery
• Improved Drug
• Release Specificity
• Therapeutic Benefits
• Factors in Pathogenesis
• RNA interference
• model organisms
• Mucor ciccinelloides
• functional genomics
• human genome
• Illustrated pharmacology for nurse
• Classification and nomenclature of drugs
• Pharmacodynamics of drugs
• Pharmacokinetics of drugs
• Adverse effects of drugs
• Drug interactions
• BMC Pharmacology and Toxicology
• Artemisinin based combination therapy
• Drug resistance
• Sub Saharan Africa
• World Health Organization
• Precision medicine
• Gene regulatory networks
• Biochemical pathways
• Active learning
• Machine learning
• Computational biology
• Materials and methods
• Heterogeneity approaches
• Image analysis tools
• Histopathology in mouse models
• Quantification of blood
• Candidate Drugs
• Toxicity of Microcystins
• Herbal Medicines
• Potential Toxicities
• Animal Models
• inclusive
• comprehensive and ratifiable
• climate change
• inefficient resource
• society organizations
• Environment and Development
• Cytochrome P450
• Interleukin 6
• Monoclonal antibody
• Therapeutic protein–drug interaction
• Multiple cytochrome P450 enzymes
• High performance liquid chromatography
• Drug excipient compatibility
• PDA detector
• Analytical wavelength
• Intermediate precision
• Pluronic – grafted copolymers
• Grafted copolymers as nanoplatforms
• Effectively delivering hydrophobic anticancer drugs
• Innovative development
• Development of an elaa kit to detect neomycin in milk
• Detect neomycin in milk
• Enzyme linked aptamer assay
• Method a variant of ELISA
• Drug resistant infection outbreaks
• capillary electrophoresis
• dodecylcarboxylic acid
• cyclic votammetry
• extrusion technique
• glycerol monooleate
• optical density
• Binding Proteins
• Posttranscriptional Networks
• Biological Macromolecules
• mRNA Stability
• Parasitic Protozoa