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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Involvement of mast cells in monocrotalineinduced pulmonary hypertension in rats. | Dahal et al. Respiratory Research 2011 12 60 http respiratory-research.eom content 12 1 60 RESPIRATORY RESEARCH RESEARCH Open Access Involvement of mast cells in monocrotaline-induced pulmonary hypertension in rats Bhola K Dahal1 Djuro Kosanovic1 Christina Kaulen1 Teodora Cornitescu1 Rajkumar Savai1 Julia Hoffmann2 Irwin Reiss3 Hossein A Ghofrani1 Norbert Weissmann1 Wolfgang M Kuebler2 4 Werner Seeger1 5 Friedrich Grimminger1 and Ralph T Schermuly1 5 Abstract Background Mast cells MCs are implicated in inflammation and tissue remodeling. Accumulation of lung MCs is described in pulmonary hypertension PH however whether MC degranulation and c-kit a tyrosine kinase receptor critically involved in MC biology contribute to the pathogenesis and progression of PH has not been fully explored. Methods Pulmonary MCs of idiopathic pulmonary arterial hypertension IPAH patients and monocrotaline-injected rats MCT-rats were examined by histochemistry and morphometry. Effects of the specific c-kit inhibitor PLX and MC stabilizer cromolyn sodium salt CSS were investigated in MCT-rats both by the preventive and therapeutic approaches. Hemodynamic and right ventricular hypertrophy measurements pulmonary vascular morphometry and analysis of pulmonary MC localization counts activation were performed in animal model studies. Results There was a prevalence of pulmonary MCs in IPAH patients and MCT-rats as compared to the donors and healthy rats respectively. Notably the perivascular MCs were increased and a majority of them were degranulated in lungs of IPAH patients and MCT-rats p 0.05 versus donor and control respectively . In MCT-rats the pharmacological inhibitions of MC degranulation and c-kit with CSS and PLX respectively by a preventive approach treatment from day 1 to 21 of MCT-injection significantly attenuated right ventricular systolic pressure RVSP and right ventricular hypertrophy RVH . Moreover vascular remodeling as evident from the significantly decreased .
