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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Lingual juvenile xanthogranuloma in a woman: a case report | Villa et al. Journal of Medical Case Reports 2011 5 30 http www.jmedicalcasereports.eom content 5 1 30 JOURNALOF medical case reports CASE REPORT Open Access Lingual juvenile xanthogranuloma in a woman a case report Alessandro Villa Umberto Mariani Francesco Villa Abstract Introduction Juvenile xanthogranuloma is a rare non-Langerhans cell histiocytosis that usually occurs during infancy and early childhood. The presence of single or multiple raised cutaneous lesions characterize this selfhealing disorder. Extracutaneous sites are rare. Case presentation We present a rare case of oral juvenile xanthogranuloma in a 49-year-old Caucasian woman. The histopathologic diagnosis of the lingual neoformation was histiocitary proliferation with the presence of giant cells Touton type compatible with juvenile xanthogranuloma. Conclusion To establish an accurate diagnosis microscopic evaluation and immunohistochemical staining are necessary. Dentists dermatologists and general practitioners may be the first to recognize this rare condition during the inspection of the oral cavity. Introduction Juvenile xanthogranuloma is an uncommon nonLangerhans cell histiocytosis that usually occurs during infancy and early childhood. This lesion was first reported by Adamson in 1905 1 who used the term congenital xanthoma multiplex. This pathological condition has subsequently been reported under various names such as nevoxanthoendothelioma juvenile xanthoma or xanthoma tuberosum 2 . Its modern name was introduced by Senear 3 in 1936 and popularized by Helwig and Hackney in 1952 4 . The pathogenesis is unknown although the disease is believed to be a reactive rather than a neoplastic process. It is caused by the proliferation of plasmacytoid monocytes in response to an unknown etiologic agent possibly either physical or infectious 5 . Juvenile xanthogranuloma is a benign and self-healing disorder which is characterized by the presence of single or multiple raised cutaneous nodules .
