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Health and Quality of Life Outcomes BioMed Central Research Open Access Self-administration and

Health and Quality of Life Outcomes BioMed Central Research Open Access Self-administration and interviewer-administration of the German Chronic Respiratory Questionnaire: instrument development and assessment of validity and reliability in two randomised studies Milo A Puhan*1, Michaela Behnke2, Martin Frey3, Thomas Grueter3, Otto Brandli4, Alfred Lichtenschopf5, Gordon H Guyatt6 and Holger J Schunemann6,7 Address: 1Horten Centre, University Hospital of Zurich, Postfach Nord CH-8091 Zurich, Switzerland, 2Ordinariat und Institut für Arbeitsmedizin, University of Hamburg, Germany, 3Klinik Barmelweid, Barmelweid, Switzerland, 4Zuercher Hoehenklinik Wald, Faltigberg-Wald, Switzerland, 5Rehabilitationszentrum, Weyer/Enns, Austria, 6Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada and 7Departments of Medicine and of Social & Preventive Medicine,. | BioMed Central Health and Quality of Life Outcomes Research Open Access Self-administration and interviewer-administration of the German Chronic Respiratory Questionnaire instrument development and assessment of validity and reliability in two randomised studies Milo A Puhan 1 Michaela Behnke2 Martin Frey3 Thomas Grueter3 Otto Brandli4 Alfred Lichtenschopf5 Gordon H Guyatt6 and Holger J Schunemann6 7 Address 1Horten Centre University Hospital of Zurich Postfach Nord CH-8091 Zurich Switzerland 2Ordinariat und Institut fur Arbeitsmedizin University of Hamburg Germany 3Klinik Barmelweid Barmelweid Switzerland 4Zuercher Hoehenklinik Wald Faltigberg-Wald Switzerland 5Rehabilitationszentrum Weyer Enns Austria 6Department of Clinical Epidemiology and Biostatistics McMaster University Hamilton Ontario Canada and 7Departments of Medicine and of Social Preventive Medicine University at Buffalo New York USA Email Milo A Puhan - milo.puhan@evimed.ch Michaela Behnke - m.behnke@uke.uni-hamburg.de Martin Frey - martin.frey@barmelweid.ch Thomas Grueter - thomasgrueter@gmx.ch Otto Brandli - otto.braendli@zhw.ch Alfred Lichtenschopf - lichtenschopf@aon.at Gordon H Guyatt - guyatt@mcmaster.ca Holger J Schunemann - hjs@buffalo.edu Corresponding author Published 08 January 2004 Received 18 November 2003 Accepted 08 January 2004 Health and Quality of Life Outcomes 2004 2 1 This article is available from http www.hqlo.cOm content 2 l l 2004 Puhan et al licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Background Assessment of health-related quality of life HRQL is important in patients with chronic obstructive pulmonary disease COPD . Despite the high prevalence of COPD in Germany Switzerland and Austria there is no validated disease-specific instrument available. The objective of this study was to .