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Báo cáo y học: "A polymorphism in the human serotonin 5-HT2A receptor gene may protect against systemic sclerosis by reducing platelet aggregation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: A polymorphism in the human serotonin 5-HT2A receptor gene may protect against systemic sclerosis by reducing platelet aggregation. | Available online http arthritis-research.eom content 10 5 R103 Research article A polymorphism in the human serotonin 5-HT2A receptor gene may protect against systemic sclerosis by reducing platelet aggregation Lorenzo Beretta1 Marta Cossu1 Maurizio Marchini1 Francesca Cappiello1 Andrea Artoni2 Giovanna Motta2 and Raffaella Scorza1 Referral Center for Systemic Autoimmune Diseases University of Milan Fondazione IRCCS Ospedale Maggiore Policlinico Mangiagalli e Regina Elena Via Pace 9 201 22 Milan Italy 2A. Bianchi Bonomi Hemophilia and Thrombosis Center Department of Medicine and Medical Specialties University of Milan IRCCS Fondazione Policlinico Mangiagalli e Regina Elena Via Pace 9 20122 Milan Italy Corresponding author Raffaella Scorza raffaella.scorza@unimi.it Received 8 Feb 2008 Revisions requested 11 Apr 2008 Revisions received 1 Aug 2008 Accepted 1 Sep 2008 Published 1 Sep 2008 Arthritis Research Therapy 2008 10 R103 doi 10.1186 ar2495 This article is online at http arthritis-research.com content 10 5 R103 2008 Beretta et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Platelet aggregation may contribute to the pathogenesis of systemic sclerosis following activation platelets release significant amounts of serotonin - which promotes vasoconstriction and fibrosis and further enhances aggregation. The C 1354T polymorphism in the exonic region of the serotonin 2A receptor gene determining the His452Tyr substitution was associated with blunted intracellular responses after serotonin stimulation and may have a role in susceptibility to scleroderma. Methods One hundred and fifteen consecutive systemic sclerosis patients and 140 well-matched healthy control individuals were genotyped by