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What! Yet another book on medical biostatistics! Why? What for? The purpose of this preface is to answer those questions and to add a few other pertinent remarks. The sections that follow describe a series of distinctions, some of them unique, that make this book different from other texts. | PRINCIPLES Of MEDICAL STATISTICS Alvan R. Feinstein M.D. CHAPMAN HALL CRC A CRC Press Company Boca Raton London New York Washington D.C. 2002 by Chapman Hall CRC Library of Congress Cataloging-in-Publication Data Feinstein Alvan R. 1925- Principles of medical statistics Alvan R. Feinstein. p. cm. Includes bibliographical references and index. ISBN 1-58488-216-6 alk. paper 1. Medicine Statistical methods. DNLM 1. Statistics methods. 2. Data Interpretation Statistical. WA 950 F299p 2001 I. Title. R853.S7 F45 2001 610 .7 27 dc21 2001001794 This book contains information obtained from authentic and highly regarded sources. Reprinted material is quoted with permission and sources are indicated. A wide variety of references are listed. Reasonable efforts have been made to publish reliable data and information but the author and the publisher cannot assume responsibility for the validity of all materials or for the consequences of their use. Neither this book nor any part may be reproduced or transmitted in any form or by any means electronic or mechanical including photocopying microfilming and recording or by any information storage or retrieval system without prior permission in writing from the publisher. The consent of CRC Press LLC does not extend to copying for general distribution for promotion for creating new works or for resale. Specific permission must be obtained in writing from CRC Press LLC for such copying. Direct all inquiries to CRC Press LLC 2000 N.W. Corporate Blvd. Boca Raton Florida 33431. Trademark Notice Product or corporate names may be trademarks or registered trademarks and are used only for identification and explanation without intent to infringe. Visit the CRC Press Web site at www.crcpress.com 2002 by Chapman Hall CRC No claim to original U.S. Government works International Standard Book Number 1-58488-216-6 Library of Congress Card Number 2001001794 Printed in the United States of America 1 2 3 4 5 6 7 8 9 0 Printed on acid-free paper 2002