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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Analysis of Gg-158(C®T) polymorphism in hemoglobin E/b-thalassemia major in Southern China | Liu et al. Journal of Hematology Oncology 2010 3 29 http www.jhoonline.Org content 3 1 29 LETTER TO THE EDITOR JOURNAL OF HEMATOLOGY ONCOLOGY Open Access Analysis of Gg-158 C T polymorphism in hemoglobin E p-thalassemia major in Southern China Rong Rong Liu Ming Yue Wang Yong Rong Lai Abstract Background The Gg-158 C T polymorphism plays important function in the clinical variability of HbE p-thalassemia. There is little known about Gg-158 C T polymorphism in HbE p-thalassemia major in Southern China. This study aimed to explore the association between HbE p-thalassemia major and this polymorphism in Southern China. Methods and Results The frequency of the Gg-158 C T polymorphism has been evaluated in 32 patients with HbE p-thalassemia major from Southern China. Further analysis of the Gg-158 C T polymorphism revealed the prominent frequency of this polymorphic pattern among HbE p-thalassemia major patients 65.63 . The presence of this polymorphism was strongly correlated with the increase of HbF synthesis. Conclusions The frequency of the Gg-158 C T polymorphism was relatively high in Southern Chinese patients with HbE p-thalassemia major often accompanying with high production of HbF. This feature appears to be different with reports in other races and regions. To the Editor Hemoglobin E p-thalassemia HbE p-thalassemia is a common form of severe thalassemia syndromes in the Southern Chinese provinces 1 . Clinical manifestations of these patients range from nearly asymptomatic to severe p-thalassemia disease. The Gg-158 C T polymorphism -158 Xmn I Gg-globin polymorphism has been shown to be associated with the increased production of HbF and can strongly influence this heterogeneity of HbE p-thalassemia 1-6 . The condition of the -158 Xmn I Gg-globin polymorphism has been rarely reported in HbE p -thalassemia majors from Southern China. The present study was to investigate the frequency of the -158 Xmn I Gg-globin polymorphism and its association with high HbF .
