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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study. | Available online http arthritis-research.eom content 9 6 R1 21 Research article Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation a basic science study Christelle Boileau 1 Nathalie Amiable1 Johanne Martel-Pelletier1 Hassan Fahmi1 Nicolas Duval2 and Jean-Pierre Pelletier1 Open Access Osteoarthritis Research Unit University of Montreal Hospital Centre Notre-Dame Hospital 1560 Sherbrooke Street East Montreal Quebec H2L 4M1 Canada 2Pavillon des Charmilles 1487 boul. des Laurentides Vimont Quebec H7M 2Y3 Canada Corresponding author Christelle Boileau christelle.boileau@umontreal.ca Received 7 Aug 2007 Revisions requested 1 Oct 2007 Revisions received 9 Oct 2007 Accepted 21 Nov 2007 Published 21 Nov 2007 Arthritis Research Therapy 2007 9 R121 doi 10.1186 ar2329 This article is online at http arthritis-research.com content 9 6 R121 2007 Boileau et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Proteinase-activated receptors PARs belong to a family of G protein-coupled receptors. PARs are activated by a serinedependent cleavage generating a tethered activating ligand. PAR-2 was shown to be involved in inflammatory pathways. We investigated the in situ levels and modulation of PAR-2 in human normal and osteoarthritis OA cartilage chondrocytes. Furthermore we evaluated the role of PAR-2 on the synthesis of the major catabolic factors in OA cartilage including metalloproteinase MMP -1 and MMP-13 and the inflammatory mediator cyclooxygenase 2 COX-2 as well as the PAR-2-activated signalling pathways in OA chondrocytes. PAR-2 expression was determined using real-time reverse transcription-polymerase .
