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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài:" Late treatment with imatinib mesylate ameliorates radiation-induced lung fibrosis in a mouse model. | Radiation Oncology BioMed Central Open Access Late treatment with imatinib mesylate ameliorates radiation-induced lung fibrosis in a mouse model Minglun Li1 5 Amir Abdollahi1 4 Hermann-Josef Grone2 Kenneth E Lipson3 6 Claus Belka5 and Peter E Huber 1 4 Address Departmentof Radiation Oncology German Cancer Research Center DKFZ Im Neuenheimer Feld 280 Heidelberg 69120 Germany 2Molecular Pathology German Cancer Research Center DKFZ Im Neuenheimer Feld 280 Heidelberg 69120 Germany 33M Pharmaceuticals St. Paul MN 55144 USA 4Department of Radiation Oncology University of Heidelberg Medical School Heidelberg 69120 Germany 5Department of Radiation Oncology University of Munich medical school Munich 81377 Germany and 6Fibrogen Inc. South San Francisco CA 94080 USA Email Minglun Li - minglun.li@med.uni-muenchen.de Amir Abdollahi - a.amir@dkfz.de Hermann-Josef Grone - h.-j.groene@dkfz.de Kenneth E Lipson - klipson@fibrogen.com Claus Belka - Claus.Belka@med.uni-muenchen.de Peter E Huber - p.huber@dkfz.de Corresponding author Published 21 December 2009 Received 24 August 2009 Accepted 21 December 2009 Radiation Oncology 2009 4 66 doi l0.ll86 l748-7l 7X-4-66 This article is available from http www.ro-journal.cOm content 4 l 66 2009 Li et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background We have previously shown that small molecule PDGF receptor tyrosine kinase inhibitors RTKI can drastically attenuate radiation-induced pulmonary fibrosis if the drug administration starts at the time of radiation during acute inflammation with present but limited effects against acute inflammation. To rule out interactions of the drug with acute inflammation we investigated here in an interventive trial if a later drug administration
