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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Intensity modulated or fractionated stereotactic reirradiation in patients with recurrent nasopharyngeal cancer. | Roeder et al. Radiation Oncology 2011 6 22 http www.ro-journal.eom content 6 1 22 RADIATION ONCOLOGY RESEARCH Open Access Intensity modulated or fractionated stereotactic reirradiation in patients with recurrent nasopharyngeal cancer 1.2 1.2 1.2 1.2 1.2 1 Falk Roeder Felix Zwicker Ladan Saleh-Ebrahimi Carmen Timke Christian Thieke Marc Bischof Juergen Debus1 2 Peter E Huber1 2 Abstract Purpose To report our experience with intensity-modulated or stereotactic reirradiation in patients suffering from recurrent nasopharyngeal carcinoma. Patients and Methods The records of 17 patients with recurrent nasopharygeal carcinoma treated by intensity-modulated n 14 or stereotactic n 3 reirradiation in our institution were reviewed. Median age was 53 years and most patients n 14 were male. The majority of tumors showed undifferentiated histology n 14 and infiltration of intracranial structures n 12 . Simultaneous systemic therapy was applied in 8 patients. Initial treatment covered the gross tumor volume with a median dose of 66 Gy 50-72 Gy and the cervical nodal regions with a median dose of 56 Gy 50-60 Gy . Reirradiation was confined to the local relapse region with a median dose of 50.4 Gy 36-64Gy resulting in a median cumulative dose of 112 Gy 91-134 Gy . The median time interval between initial and subsequent treatment was 52 months 6-132 . Results The median follow up for the entire cohort was 20 months and 31 months for survivors 10-84 . Five patients 29 developed isolated local recurrences and three patients 18 suffered from isolated nodal recurrences. The actuarial 1- and 2-year rates of local locoregional control were 76 59 and 69 52 respectively. Six patients developed distant metastasis during the follow up period. The median actuarial overall survival for the entire cohort was 23 months transferring into 1- 2- and 3-year overall survival rates of 82 44 and 37 . Univariate subset analyses showed significantly increased overall survival and local control for .