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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Comparison of outcomes in patients with stage III versus limited stage IV non-small cell lung cancer. | Cheruvu et al. Radiation Oncology 2011 6 80 http www.ro-journal.eom content 6 1 80 RADIATION ONCOLOGY RESEARCH Open Access Comparison of outcomes in patients with stage III versus limited stage IV non-small cell lung cancer Praveena Cheruvu1 Su K Metcalfe1 Justin Metcalfe1 Yuhchyau Chen1 Paul Okunieff2 and Michael T Milano1 Abstract Background Standard therapy for metastatic non small cell lung cancer NSCLC includes palliative systemic chemotherapy and or radiotherapy. Recent studies of patients with limited metastases treated with curative-intent stereotactic body radiation therapy SBRT have shown encouraging survival. We hypothesized that patients treated with SBRT for limited metastases have comparable outcomes with those treated with curative-intent radiation for Stage III NSCLC. Methods We retrospectively reviewed the records of NSCLC patients treated with curative-intent radiotherapy at the University of Rochester from 2000-2008. We identified 3 groups of patients with NSCLC stage III stage IV and recurrent stage IV initial stage I-II . All stage IV NSCLC patients treated with SBRT had 8 lesions. Results Of 146 patients 88 had KPS 80 30 had 5 weight loss and 95 were smokers. The 5-year OS from date of NSCLC diagnosis for stage III initial stage IV and recurrent stage IV was 7 14 and 27 respectively. The 5-year OS from date of metastatic diagnosis was significantly p 0.00001 superior among those with limited metastases 8 lesions versus stage III patients who developed extensive metastases not amenable to SBRT 14 vs. 0 . Conclusion Stage IV NSCLC is a heterogeneous patient population with a selected cohort apparently faring better than Stage III patients. Though patients with limited metastases are favorably selected by virtue of more indolent disease and or less bulky disease burden perhaps staging these patients differently is appropriate for prognostic and treatment characterization. Aggressive local therapy may be indicated in these patients though .
