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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Patterns of Expression of Vaginal T-Cell Activation Markers during Estrogen-Maintained Vaginal Candidiasis. | ORIGINAL ARTICLE Patterns of Expression of Vaginal T-Cell Activation Markers during Estrogen-Maintained Vaginal Candidiasis Ameera Al-Sadeq MSc Mawieh Hamad PhD and Khaled Abu-Elteen PhD The immunosuppressive activity of estrogen was further investigated by assessing the pattern of expression of CD25 CD28 CD69 and CD152 on vaginal T cells during estrogen-maintained vaginal candidiasis. A precipitous and significant decrease in vaginal fungal burden toward the end of week 3 postinfection was concurrent with a significant increase in vaginal lymphocyte numbers. During this period the percentage of CD3 CD3 CD4 CD152 and CD28 vaginal T cells gradually and significantly increased. The percentage of CD3 and CD3 CD4 cells increased from 43 and 15 at day 0 to 77 and 40 at day 28 postinfection. Compared with 29 CD152 vaginal T cells in naive mice 70 of vaginal T cells were CD152 at day 28 postinfection. In conclusion estrogen-maintained vaginal candidiasis results in postinfection time-dependent changes in the pattern of expression of CD152 CD28 and other T-cell markers suggesting that T cells are subject to mixed suppression and activation signals. Key words CD28 CD152 estrogen vaginal candidiasis vaginal T lymphocytes T 7 aginal candidiasis VC is now recognized as a major health problem for women of childbearing age worldwide.1 2 The majority of genitourinary tract fungal infections are caused by Candida albicans3 VC cases owing to C. glabrata C. tropicalis and C. kruzi are also on the rise.4 5 The majority of women who experience sporadic episodes of VC are otherwise healthy. However around 10 of women are at increased risk of VC owing to compromised immunity antibiotic overuse and increased estrogen concentration in the reproductive tract environment -3 6 Estrogen predisposes to VC by several proposed mechanisms including the enhancement of the pathogenic potential of Candida species and the suppression of host immunity.7- 11 Induction of a pseudoestrous state by .
