Đang chuẩn bị nút TẢI XUỐNG, xin hãy chờ
Tải xuống
Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Extension of the PNA world by functionalized PNA monomers eligible candidates for inverse Diels Alder Click Chemistry. | Int. J. Med. Sci. 2010 7 213 International Journal of Medical Sciences 2010 7 4 213-223 Ivyspring International Publisher. All rights reserved Research Paper Extension of the PNA world by functionalized PNA monomers eligible candidates for inverse Diels Alder Click Chemistry Manfred Wiessler1 Waldemar Waldeck2 Ruediger Pipkorn3 Christian Kliem1 Peter Lorenz1 Heinz Fleischhacker1 Manuel Hafner4 and Klaus Braun1 M 1. German Cancer Research Center Dept. of Imaging and Radiooncology INF 280 D-69120 Heidelberg Germany 2. German Cancer Research Center Division of Biophysics of Macromolecules INF 580 D-69120 Heidelberg Germany 3. German Cancer Research Center Central Peptide Synthesis Unit INF 580 D-69120 Heidelberg Germany 4. Mannheim University of Applied Sciences Department of Biotechnology Paul-Wittsack-Strafie 10 D-68163 Mannheim Germany ISI Corresponding author Dr. Klaus Braun Im Neuenheimer Feld 280 German Cancer Research Center Dep. Of Medical Physics in Radiology D-69120 Heidelberg Germany. Tel. No. 49 6221 42 2495 Fax No. 49 6221 42 3326 E-mail k.braun@dkfz. de Received 2010.03.10 Accepted 2010.06.22 Published 2010.06.27 Abstract Progress in genome research led to new perspectives in diagnostic applications and to new promising therapies. On account of their specificity and sensitivity nucleic acids DNA RNA increasingly are in the focus of the scientific interest. While nucleic acids were a target of therapeutic interventions up to now they could serve as excellent tools in the future being highly sequence-specific in molecular diagnostics. Examples for imaging modalities are the representation of metabolic processes Molecular Imaging and customized therapeutic approaches Targeted Therapy . In the individualized medicine nucleic acids could play a key role this requires new properties of the nucleic acids such as stability. Due to evolutionary reasons natural nucleic acids are substrates for nucleases and therefore suitable only to a limited extent as a drug. To
