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Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Qualitative Dosimetric and Radiobiological Evaluation of High – Dose – Rate Interstitial brachytherapy Implants. | Int. J. Med. Sci. 2008 5 41 Research Paper International Journal of Medical Sciences ISSN 1449-1907 www.medsci.org 2008 5 1 41-49 Ivyspring International Publisher. All rights reserved Qualitative Dosimetric and Radiobiological Evaluation of High - Dose -Rate Interstitial brachytherapy Implants Than S. Kehwar1 Syed F. Akber2 and Kamlesh Passi 3 1. Department of Radiation Oncology University of Pittsburgh Cancer Institute Pittsburgh PA USA. 2. Department of Radiation Oncology Case Western Reserve University Cleveland OH USA 3. Department of Radiation Oncology MD Oswal Memorial Cancer treatment and Research Center Ludhiana Pb India. Correspondence to T. S. Kehwar D.Sc. DABR Department of Radiation Oncology University of Pittsburgh Cancer Institute Robert E. Eberly Pavilion UPMC Cancer Center 51 Brewer Drive Uniontown PA 15401. Phone 724 437 2503 Fax 724 437 8846 Email drkehwar@gmail.com Received 2007.09.03 Accepted 2008.02.16 Published 2008.02.19 Radiation quality indices QI tumor control probability TCP and normal tissue complication probability NTCP were evaluated for ideal single and double plane HDR interstitial implants. In the analysis geometrically-optimized at volume GOV treatment plans were generated for different values of inter-source-spacing ISS within the catheter inter-catheter-spacing ICS and inter-plane-spacing IPS for single - and double - plane implants. The dose volume histograms DVH were generated for each plan and thecoverage volumes of 100 150 and 200 were obtained to calculate QIs tCp and NTCP. Formulae for biologically effective equivalent uniform dose BEEUD for tumor and normal tissues were derived to calculate TCP and NtCP. Optimal values of QIs except external volume index EI and TCP were obtained at ISS 1.0 cm and ICS 1.0 cm for single-plane implants and ISS 1.0 cm ICS 1.0 cm and IPS 0.75 to 1.25 cm for double - plane implants. From this study it is assessed that ISS 1.0 cm ICS 1.0 cm for single - plane implant and IPS between 0.75 cm to .
