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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Non coding extremities of the seven influenza virus type C vRNA segments: effect on transcription and replication by the type C and type A polymerase complexes | BioMed Central Virology Journal Research Non coding extremities of the seven influenza virus type C vRNA segments effect on transcription and replication by the type C and type A polymerase complexes Bernadette Crescenzo-Chaigne1 Cyril Barbezange1 2 and Sylvie van der Werf 1 Open Access Address 1Unité de Génétique Moléculaire des Virus Respiratoires URA 3015 CNRS EA 302 Université Paris Diderot Institut Pasteur F-75724 Paris France and 2UMR 1161 Virologie Afssa Inra Enva 23 avenue du Général de Gaulle 94706 Maisons-Alfort cedex France Email Bernadette Crescenzo-Chaigne - bcrescen@pasteur.fr Cyril Barbezange - c.barbezange@afssa.fr Sylvie van der Werf - svdwerf@pasteur.fr Corresponding author Published 30 October 2008 Received 23 March 2008 __ AAAO r.m J_ .IA I ioz i-7z- r - - Accepted 30 October 2008 Virology Journal 2008 5 132 doi 10.1186 1743-422X-5-132 This article is available from http www.virologyj.com content 5 1 132 2008 Crescenzo-Chaigne et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background The transcription replication of the influenza viruses implicate the terminal nucleotide sequences of viral RNA which comprise sequences at the extremities conserved among the genomic segments as well as variable 3 and 5 non-coding NC regions. The plasmid-based system for the in vivo reconstitution of functional ribonucleoproteins upon expression of viral-like RNAs together with the nucleoprotein and polymerase proteins has been widely used to analyze transcription replication of influenza viruses. It was thus shown that the type A polymerase could transcribe and replicate type A B or C vRNA templates whereas neither .
