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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Effects of plasma concentrations of 5-fluorouracil on long-term survival after treatment with a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma | Kuwahara et al. Journal of Experimental Clinical Cancer Research 2011 30 94 http www.jeccr.eom content 30 1 94 Journal of Experimental Clinical Cancer Research RESEARCH Open Access Effects of plasma concentrations of 5-fluorouracil on long-term survival after treatment with a definitive 5-fluorouracil cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma 1.2 1.2 2.3 2.4 2 Akiko Kuwahara 1 Motohiro Yamamori 1 Kaori Kadoyama Kohshi Nishiguchi Tsutomu Nakamura 2 2 2 2 2.3 Ikuya Miki Takao Tamura Tatsuya Okuno Hideaki Omatsu and Toshiyuki Sakaeda Abstract Background A substantial body of literature has accumulated during the past 20 years showing the plasma concentrations of 5-fluorouracil 5-FU to correlate with clinical response and or toxicity in colorectal cancer and head and neck cancer but little information is available concerning effects on long-term survival. Here Japanese patients with esophageal squamous cell carcinoma ESCC were followed up for 5 years after treatment with a definitive 5-FU cisplatin CDDP -based chemoradiotherapy CRT and the association between prognosis and the plasma concentration of 5-FU was evaluated. Methods Forty-nine patients with ESCC who were treated with a definitive 5-FU CDDP-based CRT were enrolled. A course consisted of the continuous infusion of 5-FU at 400 mg m2 day for days 1-5 and 8-12 the infusion of CDDP at 40 mg m2 day on days 1 and 8 and the radiation at 2 Gy day on days 1 to 5 8 to 12 and 15 to 19 with a second course repeated after a 2-week interval. Plasma concentrations of 5-FU were determined by high performance liquid chromatography at 5 00 PM on days 3 10 38 and 45 and at 5 00 AM on days 4 11 39 and 46. Results The overall 5-year survival rate was 42.9 . Age P 0.020 body weight P 0.019 and disease stage P 0.048 affected the survival and the survival depended on the clinical response assessed at 1 month after the treatment P 0.001 . Higher plasma concentrations of 5-FU .
