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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Comparison of hyperthermia and adrenaline to enhance the intratumoral accumulation of cisplatin in a murin model of peritoneal carcinomatosis | Facy et al. Journal of Experimental Clinical Cancer Research 2011 30 4 http www.jeccr.eom content 30 1 4 Journal of Experimental Clinical Cancer Research RESEARCH Open Access Comparison of hyperthermia and adrenaline to enhance the intratumoral accumulation of cisplatin in a murin model of peritoneal carcinomatosis 1.2 1 1 31 1 Olivier Facy Frangois Radais Sylvain Ladoire Delphine Delroeux Hervé Tixier Francois Ghiringhelli Patrick Rat1 2 Bruno Chauffert1 4 Pablo Ortega-Deballon1 2 Abstract Background The best method to deliver intraperitoneal chemotherapy IPC for peritoneal carcinomatosis from ovarian cancer is not well defined. The aim of this study was to assess the ability of hyperthermia and adrenaline to enhance the intratumoral accumulation of cisplatin in a rat model of peritoneal carcinomatosis. Methods Four groups of 5 BDIX rats with ovarian peritoneal carcinomatosis underwent IPC with 30 mg l of cisplatin according to the following conditions normothermia at 37 for 1 or 2 hours hyperthermia at 42 C for 1 hour or normothermia at 37 C for 2 hours with 2 mg l adrenaline. Tissue platinum content was measured by atomic absorption spectroscopy. The effect of hyperthermia adrenaline and the duration of exposure to the drug was measured in vivo tissue concentration of platinum in tumor abdominal and extra abdominal tissues and in vitro cytotoxicity on human ovarian cancer cells . Results In vitro hyperthermia and longer exposure enhanced the accumulation and the cytotoxic effect of cisplatin on cancer cells. In vivo only the 2 hours treatment with adrenaline resulted in increased platinum concentrations. The rats treated with adrenaline showed significantly lower concentrations of cisplatin in extra peritoneal tissues than those treated with hyperthermia. Conclusion Adrenaline is more effective than hyperthermia in order to enhance the intratumoral concentration of cisplatin in rats with peritoneal carcinomatosis from ovarian origin. It may also decrease the .
