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Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Initial intramuscular perfusion pressure predicts early skeletal muscle function following isolated tibial fractures | Journal of Orthopaedic Surgery and Research BioMed Central Research article Initial intramuscular perfusion pressure predicts early skeletal muscle function following isolated tibial fractures Michael Muller h Aleaxander C Dischh Nicole Zabel Norbert P Haas and Open Access Klaus D Schaser Address Charité - University Medicine Berlin Center of Musculoskeletal Surgery Berlin Germany Email Michael Muller - michael.mueller@charite.de Aleaxander C Disch - alexander.disch@charite.de Nicole Zabel - zabelnicole@aol.com Norbert P Haas - norbert.haas@charite.de Klaus D Schaser - klaus-dieter.schaser@charite.de Corresponding author fEqual contributors Published 17 April 2008 Received 20 July 2007 Journal of Orthopaedic Surgery and Research 2008 3 14 doi 10.1186 1749-799X-3-14 Accepted I7 April 2008 This article is available from http www.josr-online.eom content 3 1 14 2008 Muller et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background The severity of associated soft tissue trauma in complex injuries of the extremities guides fracture treatment and decisively determines patient s prognosis. Trauma-induced microvascular dysfunction and increased tissue pressure is known to trigger secondary soft tissue damage and seems to adversely affect skeletal muscle function. Methods 20 patients with isolated tibial fractures were included. Blood pressure and compartment pressure anterior and deep posterior compartment were measured continuously up to 24 hours. Corresponding perfusion pressure was calculated. After 4 and 12 weeks isokinetic muscle peak torque and mean power of the ankle joint in dorsal and plantar flexion were measured using a Biodex .