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Factors predisposing to colorectal cancer in UC patients consist of pancolitis, duration of disease, active disease and its severity. Early UC onset is another independent risk factor. Beside these factors, dysplasia represents the precancerous lesion from which colorectal cancer subsequently arise (Morson, 1962; Morson & Pang, 1967). In fact, 70% of patients with colorectal cancer on UC have dysplasia on colorectal mucosa (Taylor et al., 1992; Connell et al., 1994). Severe dysplasia is reported to develop colorectal cancer in 45% of cases, whereas there are too few data in literature to do a similar valuation for mild-moderate dysplasia (Collins. | SKIN BIOPSY -PERSPECTIVES Edited by Uday Khopkar INTECHWEB.ORG Skin Biopsy - Perspectives Edited by Uday Khopkar Published by InTech Janeza Trdine 9 51000 Rijeka Croatia Copyright 2011 InTech All chapters are Open Access distributed under the Creative Commons Attribution 3.0 license which permits to copy distribute transmit and adapt the work in any medium so long as the original work is properly cited. After this work has been published by InTech authors have the right to republish it in whole or part in any publication of which they are the author and to make other personal use of the work. Any republication referencing or personal use of the work must explicitly identify the original source. As for readers this license allows users to download copy and build upon published chapters even for commercial purposes as long as the author and publisher are properly credited which ensures maximum dissemination and a wider impact of our publications. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials instructions methods or ideas contained in the book. Publishing Process Manager Dragana Manestar Technical Editor Teodora Smiljanic Cover Designer Jan Hyrat Image Copyright Aaron Amat 2011. Used under license from Shutterstock.com First published October 2011 Printed in Croatia A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from orders@intechweb.org Skin Biopsy - Perspectives Edited by Uday Khopkar p. cm. ISBN 978-953-307-290-6 ikrrr iJ OPEN ACCESS INI Cvn PUBLISHER INTECH open free online editions of InTech Books and Journals can be found at .