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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Reduction of neutrophil activity decreases early microvascular injury after subarachnoid haemorrhage | Friedrich et al. Journal of Neuroinflammation 2011 8 103 http www.jneuroinflammation.eom content 8 1 103 JIOURNAL1 OF. NEUROINFLAMMATION RESEARCH Open Access Reduction of neutrophil activity decreases early microvascular injury after subarachnoid haemorrhage 12 2 2 3 1.2 Victor Friedrich Rowena Flores Artur Muller Weina Bi Ellinor IB Peerschke and Fatima A Sehba 1 Abstract Background Subarachnoid haemorrhage SAH elicits rapid pathological changes in the structure and function of parenchymal vessels 100 pm . The role of neutrophils in these changes has not been determined. This study investigates the role of neutrophils in early microvascular changes after SAH Method Rats were either untreated treated with vinblastine or anti-polymorphonuclear PMN serum which depletes neutrophils or treated with pyrrolidine dithiocarbamate PDTC which limits neutrophil activity. SAH was induced by endovascular perforation. Neutrophil infiltration and the integrity of vascular endothelium and basement membrane were assessed immunohistochemically. Vascular collagenase activity was assessed by in situ zymography. Results Vinblastine and anti-PMN serum reduced post-SAH accumulation of neutrophils in cerebral vessels and in brain parenchyma. PDTC increased the neutrophil accumulation in cerebral vessels and decreased accumulation in brain parenchyma. In addition each of the three agents decreased vascular collagenase activity and post-SAH loss of vascular endothelial and basement membrane immunostaining. Conclusions Our results implicate neutrophils in early microvascular injury after SAH and indicate that treatments which reduce neutrophil activity can be beneficial in limiting microvascular injury and increasing survival after SAH. Background Subarachnoid haemorrhage SAH is followed by pathological alterations in cerebral microvasculature 100 pm 1-6 . These alterations develop rapidly 24 hours and affect vascular structure and function. The structural alterations include corrugation and
