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Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Comparison of cardiac function and coronary angiography between conventional pigs and micropigs as measured by multidetector row computed tomography | J. Vet. Sci. 2008 9 2 121-126 JOURNAL OF Veterinary Science Comparison of cardiac function and coronary angiography between conventional pigs and micropigs as measured by multidetector row computed tomography 2.3.4.t 1 t 2 5 234 Young Keun Ahn Jung Min Ryu Hea Chang Jeong Yun Hyeon Kim Myung Ho Jeong Min Young 1 1 1.1 1 1 Lee Sang Hun Lee Jae Hong Park Seung Pil Yun Ho Jae Han College of Veterinary Medicine Biotherapy Human Resources Center Chonnam National University Gwangju 500-757 Korea 2The Heart Center 3Cardiovascular Research Institute 4Clinical Trial Center and 5Department of Radiology Chonnam National University Hospital Gwangju 501-757 Korea Pigs are the most likely source animals for cardiac xenotransplantation. However an appropriate method for estimating the cardiac function of micropigs had not been established. Computed tomography CT analysis aimed at estimating cardiac function and assessing the coronary arteries has not been carried out in micropigs. This study determined the feasibility of evaluating cardiac function in a micropig model using multidetector row computed tomography MDCT and compared the cardiac function values with those of conventional pigs. The mean age of the conventional pigs and micropigs was approximately 80 days and approximately 360 days respectively. The mean body weight in the conventional pigs and micropigs was 29.70 0.73 and 34.10 0.98 kg respectively. Cardiac MDCT detected ejection fractions of 52.93 3.10 and 59.00 5.56 and cardiac outputs of 1.46 0.64 l min and 1.21 0.24 l min in conventional pigs and micropigs respectively. There were no significant differences in cardiac function between conventional pigs and micropigs in the reconstructed CT images. There were also no differences in the coronary angiographic images obtained by MDCT. It is expected that the results of this study will help improve understanding of cardiac function in micropigs. The data presented in this study suggest that MDCT is a feasible method for
