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The HHS Pandemic Influenza Plan has three parts, the first two of which are contained in this document. Part 1, the Strategic Plan outlines federal plans and preparation for public health and medical support in the event of a pandemic. It identifies key roles of HHS and its agencies in a pandemic and provides planning assumptions for federal, state and local governments and public health operations plans. Part 2, Public Health Guidance for State and Local Partners, provides detailed guidance to state and local health departments in 11 key areas. Parts 1 and 2 will be regularly updated and refined. These documents will serve as. | Background Among patients treated medically several approaches are used depending in part on the severity of symptoms and clinical Effective Health Care Program Management Strategies for Gastroesophageal Reflux Disease An Update Executive Summary Gastroesophageal reflux disease GERD is one of the most common health conditions affecting Americans. A study of an employed population in the United States estimated that more than 11 000 of 267 000 employees 4 percent suffered from GERD contributing an average incremental cost to the employer of 3 355 per employee during a 3-year observation period approximately 65 percent related to prescription drugs.1 At the same time it is well recognized that some drugs used to treat GERD such as proton pump inhibitors are overprescribed.2 A number of patients have frequent severe symptoms requiring long-term regular use of antireflux medications. For these individuals with chronic GERD most authorities consider the goals of therapy to be an improvement in symptoms and quality of life healing and maintenance of healed erosive esophagitis and prevention of complications such as Barrett s esophagus esophageal stricture formation or esophageal adenocarcinoma . However there remains considerable uncertainty regarding how these objectives should be achieved. Comparative Effectiveness Review Number 29 Effective Health Care Program The Effective Health Care Program was initiated in 2005 to provide valid evidence about the comparative effectiveness of different medical interventions. The object is to help consumers health care providers and others in making informed choices among treatment alternatives. Through its Comparative Effectiveness Reviews the program supports systematic appraisals of existing scientific evidence regarding treatments for high-priority health conditions. It also promotes and generates new scientific evidence by identifying gaps in existing scientific evidence and supporting new research. The program puts special .