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Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: Quantitative Trait Loci (QTLs) mapping for growth traits in the mouse: A review | 105 Genet Sei. Evol. 33 2001 105-132 INRA EDP Sciences 2001 Review Quantitative Trait Loci QTLs mapping for growth traits in the mouse A review Pablo M. Corva Juan F. Medrano Department of Animal Science University of California One Shields Ave. Davis CA 95616-8521 USA Received 4 July 2000 accepted 28 November 2000 Abstract - The attainment of a specific mature body size is one of the most fundamental differences among species of mammals. Moreover body size seems to be the central factor underlying differences in traits such as growth rate energy metabolism and body composition. An important proportion of this variability is of genetic origin. The goal of the genetic analysis of animal growth is to understand its genetic architecture that is the number and position of loci affecting the trait the magnitude of their effects allele frequencies and types of gene action. In this review the different strategies developed to identify and characterize genes involved in the regulation of growth in the mouse are described with emphasis on the methods developed to map loci contributing to the regulation of quantitative traits QTLs . genetics growth mouse mapping QTLs 1. introduction The mature body size of an animal is determined by the number and size of its cells and the amount of extracellular matrix and fluid 23 with cell number making a major contribution 2 . A crucial feature of the development of mammals is that at a given point an animal stops growing reaching at that point a maximum cell mass. It is accepted that the genetic makeup of the individual plays a predominant role in the determination of that endpoint but the underlying genetic mechanisms are not well understood 23 . Therefore one of the primary objectives of the genetic analysis of animal growth is to understand its genetic architecture that is the number and position of loci affecting the trait the magnitude of their effects allele frequencies and types of gene action 12 128 . The mouse has been .
