TAILIEUCHUNG - Báo cáo khoa hoc:" Power for mapping quantitative trait loci in crosses between outbred lines in pigs"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: Power for mapping quantitative trait loci in crosses between outbred lines in pigs | Genet. Sei. Evol. 31 1999 351-374 Inra Elsevier Paris 351 Original article Power for mapping quantitative trait loci in crosses between outbred lines in pigs Luis Gomez-Raya Erling Sehested Department of Animal Science Agricultural University of Norway Box 5025 N-1432 Ảs Norway Received 28 May 1998 accepted 12 May 1999 Abstract - Power for mapping quantitative trait loci using crosses between segregating populations was studied in pigs. Crossing generates gametic disequilibrium and increases heterozygosity. The condition for a heterozygosity among Fl individuals to be greater than in either line at crossing is that allele frequency should be lower than 1 2 in one line and higher than 1 2 in the other line. Maximum expected power and expected risk were used to compare hierarchical backcross each boar mated to several sows contrast within boars hierarchical intercross each boar mated to several sows contrast within both boars and sows and traditional intercross each boar mated to one sow contrast within both boars and sows . The use of hierarchical designs back-cross and intercross increased power for traits with low or intermediate heritabilities. For small QTL effects and low heritabilities the hierarchical backcross design gave the highest expected power but also the highest risk. There is not a general design which allocates resources in an optimum fashion across situations heritabilities QTL effect heterozygosity . A compromise between designs with high power and low risk is suggested. A hierarchical backcross design of 400 piglets and heterozygosity requires between four maximum expected power and eight boars minimum risk to detect a QTL of phenotypic standard deviations. Selection of extreme individuals in parental lines increased power up to 21 . Commercial crosses are proposed as an alternative to experiments for QTL mapping. Inra Elsevier Paris gene mapping quantitative trait locus statistical power hierarchical design pig Resume Puissance de .

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