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Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Comparison of a small volume of hypertonic saline solution and dextran 40 on hemodynamic alternations in conscious calves | J. Vet. Sci. 2005 6 2 111-116 JOURNAL OF Veterinary Science Comparison of a small volume of hypertonic saline solution and dextran 40 on hemodynamic alternations in conscious calves Kazuyuki Suzuki1 Tomoko Suzuki1 Mitsuyoshi Miyahara Shigehiro Iwabuchi2 Ryuji Asano1 Department of Veterinary Medicine College of Bioresource Sciences Nihon University 1866 Kameino Fujisawa Kanagawa 2528510 Japan 2Central Research Laboratories Nippon Zenyaku Kogyo 1-1 Aza Tairanoue Sasagawa Asakamachi Koriyama Fukushima 9630196 Japan The hemodynamic effects of rapid intravenous IV administration of 10 dextran 40 in saline solution D40 and 7.2 hypertonic saline solution HSS in calves were compared. Calves received isotonic saline solution ISS HSS or D40 3 calves group and were monitored of blood pressure and cardiac output CO for 180 min. HSS and D40 infusions induced a significant increase in relative plasma volume reaching 134.9 2.8 and 125.0 1.9 respectively at the end of fluid infusion. In the HSS group CO cardiac index CI and stroke volume SV remained constant at low levels after 90 minutes despite the maximal values of CO CI and SV at the end of infusion reaching 21.0 6.3 l min p 0.05 177.8 14.2 ml min kg p 0.001 and 0.20 0.03 l beat at t 10 min p 0.001 respectively. In contrast CI and SV in the D40 group showed significant increases to 14.7 2.9 l min and 153.5 17.2 ml min kg respectively at the end of fluid infusion. And those values remained constant at higher levels than those of the before infusions values throughout the experimental periods. Positive effects for hemodynamic alternations of D40 in calf practice were milder and longer than those of HSS. Therefore the D40 infusion should be explored as a possible treatment for dehydrated calves since rapid infusion of D40 may be safe and more beneficial for rehydrating more than HSS treatment. Key words calf cardiac output dextran hemodynamic hypertonic saline Calf diarrhea remains a major cause of economic loss to cattle .
