Đang chuẩn bị nút TẢI XUỐNG, xin hãy chờ
Tải xuống
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Interaction Between Nano-Anatase TiO2 and Liver DNA from Mice In Vivo | Nanoscale Res Lett 2010 5 108-115 DOI 10.1007 s11671-009-9451-2 NANO EXPRESS Interaction Between Nano-Anatase TiO2 and Liver DNA from Mice In Vivo Na Li Linglan Ma Jue Wang Lei Zheng Jie Liu Yanmei Duan Huiting Liu Xiaoyang Zhao Sisi Wang Han Wang Fashui Hong Yaning Xie Received 14 August 2009 Accepted 24 September 2009 Published online 13 October 2009 to the authors 2009 Abstract Nano-TiO2 was shown to cause various toxic effects in both rats and mice however the molecular mechanism by which TiO2 exerts its toxicity is poorly understood. In this report an interaction of nano-anatase TiO2 with liver DNA from ICR mice was systematically studied in vivo using ICP-MS various spectral methods and gel electrophoresis. We found that the liver weights of the mice treated with higher amounts of nano-anatase TiO2 were significantly increased. Nano-anatase TiO2 could be accumulated in liver DNA by inserting itself into DNA base pairs or binding to DNA nucleotide that bound with three oxygen or nitrogen atoms and two phosphorous atoms of dNA with the Ti-O N and Ti-P bond lengths of 1.87 and 2.38 A respectively and alter the conformation of DNA. And gel electrophoresis showed that higher dose of nanoanatase TiO2 could cause liver DNA cleavage in mice. Keywords Nano-anatase TiO2 Mice DNA Binding information DNA cleavage Na Li Linglan Ma Jue Wang and Lei Zheng contributed equally to this work. N. Li L. Ma J. Wang L. Zheng J. Liu Y. Duan H. Liu X. Zhao S. Wang H. Wang F. Hong H Medical College of Soochow University 215123 Suzhou People s Republic of China e-mail Hongfsh_cn@sina.com Y. Xie Synchrotron Radiation Laboratory Institute of High Energy Physics The Chinese Academy of Science 100039 Beijing People s Republic of China Introduction Titanium dioxide TiO2 a natural nonsilicate mineraloxide occurs in different forms and is widely used in the cosmetics pharmaceutical and paint industries as a coloring material because of its high stability anticorrosion and photocatalysis. With
