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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Laboratory, One Cyclotron Road, Berkeley, California 94720. | Open Access Three-dimensional morphology and gene expression in the Drosophila blastoderm at cellular resolution II dynamics Soile VE Keranen Charless C Fowlkes Cris L Luengo Hendriks Damir Sudar David W Knowles Jitendra Malik and Mark D Biggin Addresses Berkeley Drosophila Transcription Network Project Genomics Division Lawrence Berkeley National Laboratory One Cyclotron Road Berkeley California 94720 USA. Berkeley Drosophila Transcription Network Project Department of Electrical Engineering and Computer Science University of California Berkeley California 94720 USA. Berkeley Drosophila Transcription Network Project Life Sciences Division Lawrence Berkeley National Laboratory One Cyclotron Road Berkeley California 94720 USA. H These authors contributed equally to this work. Correspondence Mark D Biggin. Email MDBiggin@lbl.gov Published 21 December 2006 Genome Biology 2006 7 RI24 doi I0.II86 gb-2006-7- 12-r 124 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2006 7 I2 RI24 Received 1 August 2006 Revised 17 November 2006 Accepted 2l December 2006 2006 Keranen et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background To accurately describe gene expression and computationally model animal transcriptional networks it is essential to determine the changing locations of cells in developing embryos. Results Using automated image analysis methods we provide the first quantitative description of temporal changes in morphology and gene expression at cellular resolution in whole embryos using the Drosophila blastoderm as a model. Analyses based on both fixed and live embryos reveal complex previously undetected three-dimensional changes in nuclear density .
