Đang chuẩn bị nút TẢI XUỐNG, xin hãy chờ
Tải xuống
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Systematic analysis of gene expression in human brains before and after death. | Research Open Access Systematic analysis of gene expression in human brains before and after death Henriette Franz Claudia Ullmann Albert Becker Margaret Ryan Sabine Bahn Thomas Arendt Matthias Simon Svante Paabo and Philipp Khaitovich Addresses Max-Planck-Institute for Evolutionary Anthropology Deutscher Platz D-04103 Leipzig Germany. Department of Neuropathology and National Brain Tumor Reference Center University of Bonn Medical Center Sigmund-Freud-Strasse D-53105 Bonn Germany. Cambridge Centre for Neuropsychiatric Research Institute of Biotechnology University of Cambridge Tennis Court Road Cambridge CB2 1QT UK. Paul Flechsig Institute for Brain Research University of Leipzig Jahnallee D-04109 Leipzig Germany. Department of Neurosurgery University of Bonn Medical Center Sigmund-Freud-Strasse D-53105 Bonn Germany. Correspondence Philipp Khaitovich. E-mail khaitovich@eva.mpg.de Published 30 December 2005 Genome Biology 2005 6 Rll2 doi l0.ll86 gb-2005-6-l3-rll2 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2005 6 l3 Rl 12 Received 4 July 2005 Revised 23 August 2005 Accepted 6 December 2005 2005 Franz et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Numerous studies have employed microarray techniques to study changes in gene expression in connection with human disease aging and evolution. The vast majority of human samples available for research are obtained from deceased individuals. This raises questions about how well gene expression patterns in such samples reflect those of living individuals. Results Here we compare gene expression patterns in two human brain regions in postmortem samples and in material collected during surgical