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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: The two tempos of nuclear pore complex evolution: highly adapting proteins in an ancient frozen structure . | Research Open Access The two tempos of nuclear pore complex evolution highly adapting proteins in an ancient frozen structure Eric BaptesteH Robert L Charlebois Dave MacLeod and Céline BrochierH Addresses Canadian Institute for Advanced Research Program in Evolutionary Biology Department of Biochemistry and Molecular Biology Dalhousie University College Street Halifax Nova Scotia B3H 1X5 Canada. ỶGenome Atlantic Department of Biochemistry and Molecular Biology Dalhousie University 5850 College Street Halifax Nova Scotia B3H 1X5 Canada. EA EGEE Evolution Génome Environnement Centre Saint-Charles Université Aix-Marseille I place Victor Hugo 13331 Marseille Cedex 3 France. H These authors contributed equally to this work. Correspondence Céline Brochier. E-mail celine.brochier@up.univ-mrs.fr Published 30 September 2005 Genome Biology 2005 6 R85 doi 10.1 186 gb-2005-6-10-r85 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2005 6 10 R85 Received 23 March 2005 Revised 15 July 2005 Accepted 1 September 2005 2005 Bapteste et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The origin of the nuclear compartment has been extensively debated leading to several alternative views on the evolution of the eukaryotic nucleus. Until recently too little phylogenetic information was available to address this issue by using multiple characters for many lineages. Results We analyzed 65 proteins integral to or associated with the nuclear pore complex NPC including all the identified nucleoporins the components of their anchoring system and some of their main partners. We used reconstruction of ancestral sequences of these proteins to expand the detection of .
