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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: The biology of genomes: sequence gives way to function. | Meeting report The biology of genomes sequence gives way to function David A Hinds Address Perlegen Sciences 2021 Stierlin Court Mountain View CA 94043 USA. E-mail dhinds@perlegen.com Published 30 August 2005 Genome Biology 2005 6 342 doi 10.1186 gb-2005-6-9-342 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2005 6 9 342 2005 BioMed Central Ltd A report on the meeting The Biology of Genomes Cold Spring Harbor USA 11-15 May 2005. This year s Cold Spring Harbor meeting The Biology of Genomes presented an eye-opening snapshot of how far the field has come since the sequencing of the human genome was completed. A common theme of the meeting was the integration of new whole-genome variation and comparative genomic datasets with high-throughput experimental methods to address biological questions that might previously have been answerable only on the scale of a single locus if at all. Speakers discussed the systematic identification of functional sequence elements detection of relationships between these elements and biological endpoints and reconstruction of their evolutionary histories. Many of these whole-genome analyses raise questions of how to deal with incomplete coverage and nonrandom sampling how to evaluate significance when many statistical tests are performed and how to properly account for both false-positive and false-negative results in very large and complex datasets. It seems clear that much work remains to be done to sort out these statistical issues. New genomics datasets deeper and broader The Encyclopedia of DNA Elements ENCODE project has the goal of characterizing all human functional genetic elements initially in 44 selected intervals representing about 1 of the genome. Eric Green National Human Genome Research Institute NHGRI Bethesda USA presented an overview of the project. Many ENCODE annotations are now available through the University of California at Santa Cruz UCSC Genome .
