Đang chuẩn bị nút TẢI XUỐNG, xin hãy chờ
Tải xuống
Tôi thích thứ hai nhưng không phải là rẽ ¢. Noble: Trong một số trường hợp, bạn sẽ muốn nhạy cảm. Không Hodgkin ^ Huxley phân tích của một xung động thần kinh sẽ được chính xác mà không có nó là trường hợp mà ở một điểm quan trọng nhất định toàn bộ điều có o ¡. Chúng tôi sẽ cần phải có nhạy cảm với một số giá trị tham số. | 152 LOEW of such faulty models can directly motivate the discovery via new experiments of previously unknown critical biochemical or structural features required for the cellular process under investigation. Despite these clear benefits of the use of modelling as an adjunct to experiment the difficulties associated with the formulation of mathematical models and the generation of simulations from them has impeded the adoption of this disciplined and quantitative approach to research in cell biology. Because biologists rarely have sufficient training in the mathematics and physics required to build quantitative models modelling has been largely the purview of theoreticians who have the appropriate training but little experience in the laboratory. This disconnection to the laboratory has limited the impact of mathematical modelling in cell biology and in some quarters has even given modelling a poor reputation. The Virtual Cell project aims to address this problem by providing a computational modelling framework that is accessible to cell biologists. It does this by abstracting and automating the mathematical and physical operations involved in constructing models and generating simulations from them. At the same time the Virtual Cell provides a mathematical interface that allows theoreticians to examine and elaborate models through purely mathematical formulations. This dual interface has the additional benefit of encouraging communication and collaboration between the experimental and modelling communities. This paper will describe the current implementation of the Virtual Cell and briefly review some of the cell biological problems to which it has been applied. The reader is referred to other recent reviews for broader coverage of the field of computational cell biology Loew Schaff 2001 Slepchenko et al 2002 and to our website http www.nrcam.uchc.edu for a user guide and tutorial. The problem domain reaction diffusion in arbitrary geometries At its most .
