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In 1856, Rudolf Virchow published “Cellular pathology” based on macroscopic and microscopic observation of diseases, and described a triad of factors on thrombosis. The three components were vascular change, blood flow alteration, and abnormalities of blood constituents. Although Virchow originally referred to venous thrombosis, the theory can also be applied to arterial thrombosis, and it is considered that atherothrombus formation is regulated by the thrombogenicity of exposed plaque contents, local hemorheology, and blood factors. Thrombus formation on a disrupted atherosclerotic plaque is a critical event that leads to atherothrombosis. However, it does not always result in complete thrombotic occlusion with subsequent acute symptomatic events (Sato et al., 2009) | NOVEL RISK FACTORS IN ATHEROTHROMBOSIS Edited by Efrain Gaxiola TRADITIONAL AND NOVEL RISK FACTORS IN ATHEROTHROMBOSIS Edited by Efrain Gaxiola Traditional and Novel Risk Factors in Atherothrombosis Edited by Efrain Gaxiola Published by InTech Janeza Trdine 9 51000 Rijeka Croatia Copyright 2012 InTech All chapters are Open Access distributed under the Creative Commons Attribution 3.0 license which allows users to download copy and build upon published articles even for commercial purposes as long as the author and publisher are properly credited which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech authors have the right to republish it in whole or part in any publication of which they are the author and to make other personal use of the work. Any republication referencing or personal use of the work must explicitly identify the original source. As for readers this license allows users to download copy and build upon published chapters even for commercial purposes as long as the author and publisher are properly credited which ensures maximum dissemination and a wider impact of our publications. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials instructions methods or ideas contained in the book. Publishing Process Manager Anja Filipovic Technical Editor Teodora Smiljanic Cover Designer InTech Design Team First published April 2012 Printed in Croatia A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from orders@intechopen.com Traditional and Novel Risk Factors in Atherothrombosis Edited by Efrain Gaxiola p. cm. ISBN .
