Đang chuẩn bị liên kết để tải về tài liệu:
Chỉnh hình nghiên cứu

Tham khảo tài liệu 'chỉnh hình nghiên cứu', y tế - sức khoẻ, y học thường thức phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | Orthopaedic Research Society Special Article Use of Bisphosphonates to Improve the Durability of Total Joint Replacements Arun S. Shanbhag PhD MBA Dr. Shanbhag is Assistant Professor Harvard Medical School Boston MA. Dr. Shanbhag or the department with which he is affiliated has received research or institutional support from Merck. Dr. Shanbhag or the department with which he is affiliated has received nonincome support such as equipment or services commercially derived honoraria or other non-research-related funding such as paid travel from Merck. Dr. Shanbhag or the department with which he is affiliated has stock or stock options held in Merck. Supported by the National Institutes of Health NIAMS Grant AR47465 A03. Reprint requests Dr. Shanbhag Massachusetts General Hospital Biomaterials Lab GRJ 1115 55 Fruit Street Boston MA 02114. J Am Acad Orthop Surg 2006 14 215-225 Copyright 2006 by the American Academy of Orthopaedic Surgeons. Abstract Total joint arthroplasty is very effective for improving the quality of life of patients with end-stage arthritis. Despite advances in materials surgical technique and rehabilitation regimens joint replacements are still fraught with complications leading to their premature failure. Aseptic loosening and osteolysis are the primary causes of implant failure. Other reasons include early migration of components leading to instability lack of ingrowth into implant porosities and bone loss caused by stress shielding. Pharmaceutical agents used for preventing and managing postmenopausal osteoporosis eg bisphosphonates may in the future play an important role in improving the long-term duration of joint arthroplasties. Early findings indicate that bisphosphonates upregulate bone morphogenetic protein-2 production and stimulate new bone formation. Because of their anabolic effect on osteoblasts bisphosphonates have the potential to enhance bone ingrowth into implant porosities prevent bone resorption under adverse conditions and .