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Pediatric Epilepsy Diagnosis and Therapy - part 6

Kết luận của AED thành lập như là hiệu quả hoặc hiệu quả như đơn trị liệu ban đầu AED có thể hiệu quả hoặc hiệu quả như đơn trị liệu ban đầu của AED có thể hiệu quả hoặc hiệu quả như đơn trị liệu ban đầu AED có khả năng hiệu quả hoặc không hiệu quả đơn trị liệu ban đầu như | 31 EVIDENCE-BASED MEDICINE ISSUES RELATED TO DRUG SELECTION 437 TABLE 31-3 Relationship Between Clinical Trial Ratings Level of Evidence and Conclusions for ILAE Guideline on Initial Monotherapy for Adults and Children with Epilepsy 1 Combination s of Clinical Trial Ratings Level of Evidence Conclusions Recommendation Based on Efficacy and Effectiveness Data Only 1 Class I studies or meta-analysis meeting Class I criteria sources OR 2 Class II studies A AED established as efficacious or effective as initial monotherapy AED should be considered for initial monotherapy First-line monotherapy candidate 1 Class II study or meta-analysis meeting Class II criteria B AED probably efficacious or effective as initial monotherapy 2 Class III double-blind or open label studies 1 Class III double blind or open label study OR 1 Class IV clinical studies OR Data from expert committee reports opinions from experienced clinicians C D AED possibly efficacious or effective as initial monotherapy AED potentially efficacious or effective as initial monotherapy AED may be considered for initial monotherapy Alternative first-line monotherapy candidates Weak efficacy or effectiveness data available to support the use of the AED for initial monotherapy Absence of directly applicable clinical evidence upon which to base a recommendation E No data available to assess if AED is effective as initial monotherapy Either no data or inadequate efficacy or effectiveness data available to decide whether AED could be considered for initial monotherapy Positive evidence of lack of efficacy or effectiveness based on Class I to IV studies OR Significant risk of seizure aggravation based on Class I to IV studies F AED established as ineffective or significant risk of seizure aggravation AED should not be used for initial monotherapy 1 munoui n 1 IUVB Variable ILAE AAN AES Team N 10 6 countries N 24 1 country AEDs examined 31 AEDs 7 newer US AEDs Study years 1940-present 1987-2003 Scoring system I LAE .