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From HIV to influenza, the battle between infectious agents and the immune system is at the heart of disease. Knowledge of how and why parasites vary to escape recognition by the immune system is central to vaccine design, the control of epidemics, and our fundamental understanding of parasite ecology and evolution. As the first comprehensive synthesis of parasite variation at the molecular, population, and evolutionary levels, this book is essential reading for students and researchers throughout biology and biomedicine | Immunology and Evolution of Infectious Disease Steven A. Frank Immunology and Evolution of Infectious Disease STEVEN A. FRANK Princeton University Press Princeton and Oxford This is a full PDF copy of Frank S. A. 2002. Immunology and Evolution of Infectious Disease. Princeton University Press. This PDF is a trial version of the book. If you intend to read and use the book you should buy a copy at http pup.princeton.edu http amazon.com http bn.com or your local bookseller. A copy of this PDF and other information about the book is available at http stevefrank.org Copyright 2002 by Steven A. Frank Published by Princeton University Press 41 William Street Princeton New Jersey 08540 In the United Kingdom Princeton University Press 3 Market Place Woodstock Oxfordshire OX20 1SY All Rights Reserved Library of Congress Cataloging-in-Publication Data Frank Steven A. 1957- Immunology and Evolution of Infectious Disease Steven A. Frank. p. cm. Includes bibliographic references and index. ISBN 0-691-09594-9 cloth alk. paper ISBN 0-691-09595-7 pbk. alk. paper 1. Immunogenetics. 2. Host-parasite relationships Genetic aspects. 3. Microorganisms Evolution. 4. Antigens. 5. Molecular evolution. 6. Parasite antigens Variation. I. Title. DNLM 1. Communicable Diseases immunology. 2. Evolution Molecular. 3. Genetics Population. 4. Immunity genetics. WC 100 F828i 2002 QR184 .F73 2002 616.9 0479 dc21 2002018384 British Library Cataloging-in-Publication Data is available Typeset by the author with TEX Composed in Lucida Bright Printed on acid-free paper. e www.pupress.princeton.edu Printed in the United States of America 10 987654321 10 987654321 Pbk.