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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Invasive ventilation modes in children: a systematic review and meta-analysis. | Duyndam et al. Critical Care 2011 15 R24 http ccforum.eom content 15 1 R24 KS CRITICAL CARE RESEARCH Open Access Invasive ventilation modes in children a systematic review and meta-analysis Anita Duyndam Erwin Ista Robert Jan Houmes Bionda van Driel Irwin Reiss Dick Tibboel Abstract Introduction The purpose of the present study was to critically review the existing body of evidence on ventilation modes for infants and children up to the age of 18 years. Methods The PubMed and EMBASE databases were searched using the search terms artificial respiration instrumentation device devices mode and modes . The review included only studies comparing two ventilation modes in a randomized controlled study and reporting one of the following outcome measures length of ventilation LOV oxygenation mortality chronic lung disease and weaning. We quantitatively pooled the results of trials where suitable. Results Five trials met the inclusion criteria. They addressed six different ventilation modes in 421 children high-frequency oscillation HFO pressure control PC pressure support PS volume support VS volume diffusive respirator VDR and biphasic positive airway pressure. Overall there were no significant differences in LOV and mortality or survival rate associated with the different ventilation modes. Two trials compared HFO versus conventional ventilation. In the pooled analysis the mortality rate did not differ between these modes odds ratio 0.83 95 confidence interval 0.30 to 1.91 . High-frequency ventilation HFO and VDR was associated with a better oxygenation after 72 hours than was conventional ventilation. One study found a significantly higher PaO2 FiO2 ratio with the use of VDR versus PC ventilation in children with burns. Weaning was studied in 182 children assigned to either a PS protocol a VS protocol or no protocol. Most children could be weaned within 2 days and the weaning time did not significantly differ between the groups. Conclusions The literature provides scarce
