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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Modeling gene sequences over time in 2009 H1N1 Influenza A Virus populations | Virology Journal BioMed Central Open Access Modeling gene sequences over time in 2009 MINI Influenza A Virus populations Natalia Goni Alvaro Fajardo Gonzalo Moratorio Rodney Colina and Juan Cristina Address Laboratorio de Virología Molecular Centro de Investigaciones Nucleares Facultad de Ciencias Igua 4225 11400 Montevideo Uruguay Email Natalia Goni - tati24@adinet.com.uy Alvaro Fajardo - afajardo@cin.edu.uy Gonzalo Moratorio - moratorio@pasteur.edu.uy Rodney Colina - rcolina@cin.edu.uy Juan Cristina - cristina@cin.edu.uy Corresponding author Published 4 December 2009 Received 28 September 2009 Accepted 4 December 2009 Virology Journal 2009 6 215 doi 10.1186 1743-422X-6-215 This article is available from http www.virologyj.com content 6 1 215 2009 Goni et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.Org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background A sudden emergence of Influenza A Virus IAV infections with a new pandemic HINI IAV is taking place since April of 2009. In order to gain insight into the mode of evolution of these new HI NI strains we performed a Bayesian coalescent Markov chain Monte Carlo MCMC analysis of full-length neuraminidase NA gene sequences of 62 HINI IAV strains isolated from March 30th to by July 28th 2009 . Results The results of these studies revealed that the expansion population growth model was the best to fit the sequence data. A mean of evolutionary change of 7.84 X I0-3 nucleotide substitutions per site per year s s y was obtained for the NA gene. A significant contribution of first codon position to this mean rate was observed. Maximum clade credibility trees revealed a rapid diversification of NA genes in different genetic lineages all of them containing Oseltamivir-resistant viruses of very recent emergence. .
