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Báo cáo khoa học: " Characterisation of immune responses and protective efficacy in mice after immunisation with Rift Valley Fever virus cDNA constructs"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Characterisation of immune responses and protective efficacy in mice after immunisation with Rift Valley Fever virus cDNA constructsB | Virology Journal BioMed Central Research Characterisation of immune responses and protective efficacy in mice after immunisation with Rift Valley Fever virus cDNA constructs Nina Lagerqvist1 2 4 Jonas Năslund2 3 Ảke Lundkvist2 3 Michèle Bouloy5 Clas Ahlm2 and Goran Bucht 1 6 Open Access Address 1 Swedish Defence Research Agency Department of CBRN Defence and Security SE-901 82 Umeâ Sweden 2Department of Clinical Microbiology Division of Infectious Diseases Umeâ University SE-901 85 Umeâ Sweden 3Department of Clinical Microbiology Division of Virology Umeâ University SE-901 85 Umeâ Sweden 4Swedish Institute for Infectious Disease Control SE-171 82 Solna Sweden 5Institut Pasteur Unité de Génétique Moléculaire des Bunyaviridés Paris France and 6National Environment Agency Environmental Health Institute 11 Biopolis Way 06-05 08 Helios Block 138667 Singapore Email Nina Lagerqvist - nialat02@student.umu.se Jonas Năslund - jonas.naslund@climi.umu.se Ảke Lundkvist - ake.lundkvist@smi.ki.se Michèle Bouloy - mbouloy@pasteur.fr Clas Ahlm - clas.ahlm@infdis.umu.se Goran Bucht - bucht.goran@gmail.com Corresponding author Published 17 January 2009 Received 31 December 2008 Accepted 17 January 2009 Virology Journal 2009 6 6 doi l0.ll86 l743-422X-6-6 This article is available from http www.virologyj.cOm content 6 1 6 2009 Lagerqvist et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Affecting both livestock and humans Rift Valley Fever is considered as one of the most important viral zoonoses in Africa. However no licensed vaccines or effective treatments are yet available for human use. Naked DNA vaccines are an interesting approach since the virus is highly infectious and existing attenuated Rift Valley Fever virus