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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Hypothermia does not increase the risk of infection: a case control study. | Kamps et al. Critical Care 2011 15 R48 http ccforum.eom content 15 1 R48 KS CRITICAL CARE RESEARCH Open Access Hypothermia does not increase the risk of infection a case control study Marlijn Kamps Laurens LA Bisschops Johannes G van der Hoeven Cornelia WE Hoedemaekers Abstract Introduction Hypothermia may improve outcome in patients after traumatic brain injury especially when hypothermia is maintained for more than 48 hours. In the acute phase patients with severe brain injury are more vulnerable to infections. Prolonged hypothermic treatment may further enhance the risk of infection. Selective decontamination of the digestive tract SDD reduces the risk of respiratory tract infections. The aim of this study was to investigate the incidence of infections in patients treated with hypothermia and normothermia while receiving SDD. Methods In this retrospective case control study 35 patients treated with prolonged hypothermia cases were identified and 169 patients with severe brain injury were included controls . Propensity score matching was performed to correct for differences in baseline characteristics and clinical parameters. Primary outcome was the incidence of infection. The secondary endpoints were the micro-organisms found in the surveillance cultures and infection. In addition a number of clinical characteristics were assessed. Results The demographic and clinical data indicated that the cases and controls were well matched. The overall risk of infection during ICU stay was 20 in the hypothermia groups versus 34.4 in the normothermia group P 0.388 . Pneumonia was diagnosed in 11.4 of patients in both groups P 1.000 . The incidence of meningitis wound infection bacteremia and urinary tract infection was low and comparable between the groups. SDD surveillance cultures indicated a higher colonization with gram-negative bacteria in the rectal samples of the hypothermia patients. Conclusions Hypothermia does not increase the risk of infection in patients treated
