TAILIEUCHUNG - Báo cáo y học: "Changes in S-100 protein serum levels in survivors of out-of-hospital cardiac arrest treated with mild therapeutic hypothermia: a prospective, observational study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Changes in S-100 protein serum levels in survivors of out-of-hospital cardiac arrest treated with mild therapeutic hypothermia: a prospective, observational study. | Available online http content 13 2 R58 Research Changes in S-100 protein serum levels in survivors of out-of-hospital cardiac arrest treated with mild therapeutic hypothermia a prospective observational study Matthias Derwall1 2 Christian Stoppe1 David Brucken1 Rolf Rossaint1 and Michael Fries1 Department of Anaesthesiology University Hospital RWTH Aachen Pauwelsstrasse 30 52074 Aachen Germany institute of Neuropathology University Hospital RWTH Aachen Pauwelsstrasse 30 52074 Aachen Germany Corresponding author Matthias Derwall mderwall@ Received 15 Jan 2009 Revisions requested 11 Mar 2009 Revisions received 19 Mar 2009 Accepted 16 Apr 2009 Published 16 Apr 2009 Critical Care 2009 13 R58 doi cc7785 This article is online at http content 13 2 R58 2009 Derwall et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Knowledge about the influence of current neuroprotective interventions on prognostic markers after survival from cardiac arrest is lacking. This study aimed to investigate the effects of mild therapeutic hypothermia on the release of the astroglial protein S-100 after cardiopulmonary resuscitation CPR in survivors of out-of-hospital cardiac arrest. Methods This was a prospective observational study performed during a two-year period involving medical emergency services and five collaborating hospitals at the city of Aachen Germany. Sixty-eight subjects were enrolled by the emergency physician on duty by taking blood samples after successful attempts at resuscitation with return of spontaneous circulation ROSC followed by samples at 6 12 24 72 and 120 hours post ROSC by the appropriate intensive care unit staff. Depending on the decision of

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