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Tham khảo tài liệu 'converging technologies for improving human performance episode 2 part 3', kỹ thuật - công nghệ, cơ khí - chế tạo máy phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | Converging Technologies for Improving Human Performance pre-publication on-line version 227 research efforts represent the start towards interfacing with biological functions at the most fundamental level. However biology is the intertwined combination of many single molecular events each being coupled with one another either synchronously or asynchronously. To truly unveil biological events such as cell signaling pathways genetic mutation processes or the immune responses to pathogens one must have a method to generate large-scale multifunctional nano-bio interfaces with readout and control at the single biomolecule level. I provide three visions for features of the nanobiotechnology roadmap 1. The development of a biological microprocessor for synthesizing and analyzing biomolecules on nano platforms liposomes nanoparticles self-assembled monolayers and membranes in fluids. These biomolecular nanotransducers will be able to function 1 as multiplexed nanomedicines capable of long duration in vivo targeted detection diagnosis and treatment of molecular diseases 2 as key ingredients of smart coatings for versatile environmental monitoring of toxins pathogens and 3 as engineered biomolecular nanosystems that mimic cellular functions for fundamental biology experiments. 2. The coupling of biomolecular units whether they be DNA receptors antibodies or enzymes with MEMS for reassembly of cell components and reprogrammed cell functions. This will enable the rewiring of biological cell pathways in artificially controlled platforms such that it will be possible to carry out preclinical experiments without the use of animals or humans. 3. The coupling of nano guards for health e.g. nanoparticles with microfluidic controllers for long-term control of certain health parameters. For instance the feedback loop of a glucose sensor and delivery of nano artificial islets can enable the merging of detection diagnosis and treatment into one MEMS device. Artificial Brains and Natural
