Đang chuẩn bị nút TẢI XUỐNG, xin hãy chờ
Tải xuống
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Local hyperthermia decreases the expression of CCL-20 in condyloma acuminatum | Wang et al. Virology Journal 2010 7 301 http www.virologyj.eom content 7 1 301 VIROLOGY JOURNAL RESEARCH Open Access Local hyperthermia decreases the expression of CCL-20 in condyloma acuminatum Xiaoqin Wang1 2 Xing-Hua Gao1 Yuxiao Hong1 Xiaodong Li1 Hong-Duo Chen1 Abstract Background Local hyperthermia has been successfully used in the treatment of viral warts. However the mechanism of action has largely remained unclear. CCL-20 also known as MIP-3a is the most potent chemokine for recruitment of Langerhans cell LC precursors into the skin. CCL-20 expression can be increased by TNF-a and IL-1a. The effects of local hyperthermia on the mRNA expressions of CCL-20 TNF-a IL-1a have been investigated in both condyloma acuminata CA and normal skin. Under an organotypic culture condition fresh CA and normal skin were subjected to surface heating at 37 C 42 C and 45 C for 30 mins respectively. Results The mRNA expressions of CCL-20 and IL-1a in CA specimen were significantly higher than those in normal skin. Local hyperthermia at 42 C and 45 C significantly decreased the mRNA levels of CCL-20 and IL-1a as compared with the control groups p 0.01 . The decrease of CCL-20 was well correlated with that of IL-1a. The expression of TNF-a in CA remained unchanged in spite of the temperature variation. Local hyperthermia at 45 C concomitantly increased the mRNA expression of CCL-20 and IL-1a in normal skin. Conclusions Our study suggests that hyperthermia decreases the expression of CCL-20 with concomitant decrease in IL-1a and reduce the number of Langerhans cells in HPV infected skin. Background Human papillomavirus HPV is a group of circular-DNA viruses that could induce proliferation and under certain circumstance the malignant transformation of epithelial cells in humans 1 . HPV infection of human skin or mucosa results in a variety of clinical entities e.g. common warts plantar warts condyloma acuminata CA etc primarily based on the anatomical sites and the invading types .
