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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Application of methods of identifying receptor binding models and analysis of parameters | Theoretical Biology and Medical Modelling BioMed Central Research Open Access Application of methods of identifying receptor binding models and analysis of parameters Konstantin G Gurevich Address UNESCO Chair in healthy life for sustainable development Moscow State Dentistry Medical University MSDMU Delegatskaya street 20 1 127473 Moscow Russian Federation Russia Email Konstantin G Gurevich - kgurevich@newmail.ru Corresponding author Published 16 November 2004 Received 15 August 2004 Accepted 16 November 2004 Theoretical Biology and Medical Modelling 2004 1 11 doi 10.1186 I742-4682-I-II r This article is available from http www.tbiomed.com content 1 1 1 1 2004 Gurevich licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Possible methods for distinguishing receptor binding models and analysing their parameters are considered. Results and Discussion The conjugate gradients method is shown to be optimal for solving problems of the kind considered. Convergence with experimental data is rapidly achieved with the appropriate model but not with alternative models. Conclusion Lack of convergence using the conjugate gradients method can be taken to indicate inconsistency between the receptor binding model and the experimental data. Thus the conjugate gradients method can be used to distinguish among receptor binding models. Background Most medicinal preparations and biologically active substances do not penetrate into cells and must therefore exert their influence on intracellular processes by interaction with specific protein molecules at the cell surface 13 for which the name receptors is in common use. Hormones and drugs that interact with receptors are known as ligands . Data from research in molecular biology .
