TAILIEUCHUNG - Báo cáo y học: "Reconstruction and flux analysis of coupling between metabolic pathways of astrocytes and neurons: application to cerebral hypoxia"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: "Reconstruction and flux analysis of coupling between metabolic pathways of astrocytes and neurons: application to cerebral hypoxia | Theoretical Biology and Medical Modelling BioMed Central Research Reconstruction and flux analysis of coupling between metabolic pathways of astrocytes and neurons application to cerebral hypoxia Tunahan Qakir1 Selma Alsan1 Hale Saybasili2 Ata Akin2 and Kutlu Ỏ ulgen 1 Address Department of Chemical Engineering Bogazitji University 34342 Bebek. Istanbul Turkey and institute of Biomedical Engineering Bogazitji University 34342 Bebek. Istanbul Turkey Email Tunahan Ọaktr - tcakir@ Selma Alsan - selmaalsan@ Hale Saybasili - saybasil@ Ata Akin - Kutlu o ulgen - ulgenk@ Corresponding author Open Access Published 10 December 2007 Received 24 June 2007 Theoretical Biology and Medical Modelling 2007 4 48 doi 1742-4682-4-48 Accepted 10 December 2007 This article is available from http content 4 1 48 2007 Ọakr et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background It is a daunting task to identify all the metabolic pathways of brain energy metabolism and develop a dynamic simulation environment that will cover a time scale ranging from seconds to hours. To simplify this task and make it more practicable we undertook stoichiometric modeling of brain energy metabolism with the major aim of including the main interacting pathways in and between astrocytes and neurons. Model The constructed model includes central metabolism glycolysis pentose phosphate pathway TCA cycle lipid metabolism reactive oxygen species ROS detoxification amino acid metabolism synthesis and catabolism the well-known glutamate-glutamine cycle other coupling reactions between astrocytes and neurons and neurotransmitter metabolism. This is to our knowledge the most

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